Mariota finished 24-for-31 through the air and also rushed for 88 yards on 13 carries as the Ducks (6-0, 3-0 Pac-12) rolled to a third straight conference victory.
Bralon Addison hauled down eight passes for 157 yards with two touchdowns, while Byron Marshall paced Oregon's ground attack, gaining 106 yards and scoring twice on 19 carries.
The Huskies (4-2, 1-2) fell to the their second straight loss as Keith Price was limited to 182 passing yards, one touchdown and one interception on 19-for-32 efficiency.
Bishop Sankey amassed 167 rushing yards with two scores on 28 carries for Washington.
Swim Week Miami Beach 2014 [PHOTOS]