The Bruins defense picked off Wilson for the final time with 24 seconds left in the contest as the Utes tried for a potential game-tier at 12th-ranked UCLA's 23-yard line.
Brett Hundley was good for 17-of-27 passes for 211 yards with one touchdown and one interception for UCLA (4-0, 1-0 Pac-12), which has gone 4-0 for the first time since 2005.
Paul Perkins had 16 carries for 92 yards, Jordan Payton caught three passes for 68 yards and one TD and Anthony Barr contributed two sacks for the Bruins.
Wilson was 22-of-44 for 288 yards and two TDs for the Utes (3-2, 0-2).
Dres Anderson had six catches for 106 yards and a TD while Sean Fitzgerald caught five for 53 yards and a TD for Utah.