Manziel went 23-of-30 for 261 passing yards and Trey Williams led a powerful ground game with 83 yards and a score on nine carries for the Aggies (4-1, 1-1 SEC).
Ben Malena added 40 yards with two touchdowns on 12 carries and Manziel chipped in 59 yards on nine rushing attempts as Texas A&M racked up a 10th straight road win.
Deshazor Everett paced the Aggies' defense with a 34-yard interception return for a touchdown.
The Razorbacks (3-2, 0-1) fell despite 282 yards and three scores on 17-of-36 efficiency from Brandon Allen.
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