A statement indicated doctors inserted a plate and screws in Driskel's fibula while also repairing knee ligaments and an ankle injury,
The Gators' junior signal-caller was hurt early in Saturday's 31-17 win over Tennessee.
Driskel, in his second season as Florida's starting quarterback, will need 4-6 months to recover, placing his status for spring football in question, Coach Will Muschamp said.
If given medical red-shirt status, he would be available to quarterback the team in 2014 and 2015.
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