James carried the ball 19 times, scoring on TD runs of 4 and 19 yards, as the Bruins (3-0) rolled up 692 yards of total offense in the non-conference blowout.
Brett Hundley completed 23-of-36 pass attempts for 281 yards with three touchdowns and three interceptions. He also ran six times for 33 yards.
Steven Manfro, Devin Fuller and Shaquelle Evans each hauled down a TD toss for UCLA, which honored late receiver Nick Pasquale by lining up in a 10-man formation to start the game.
Pasquale, 20, was hit by a car and killed in a Sept. 8 accident in San Clemente, Calif.
Andrew McDonald and King Davis III combined to go 15-of-26 for 146 passing yards, one TD and one interception for the Aggies (0-4).