The Heisman Trophy-winner completed 14-of-21 passes for 244 yards with an interception and also ran for 102 yards as the Aggies (3-1) bounced back from a tough loss last week to top-ranked Alabama.
Ben Malena helped out the Aggies' ground game with 71 yards on 13 carries.
The Mustangs (1-2) were paced by Garrett Gilbert, who racked up 310 passing yards on 37-of-62 efficiency.
Gilbert tossed a touchdown pass and was picked off once.
Costly malfunction causes beer flood at Boston-area brewery
Megyn Kelly: Santa Claus and Jesus are both white men