Guiton, filling in for injured Braxton Miller, connected for all six TDs in the first half and went 24-for-34 with 215 yards passing for Ohio State (4-0), which extended it winning streak to 16 games -- currently the longest in college football.
Evan Spencer made four catches for 50 yards and two TDs. Ezekial Elliott carried the ball 14 times for 162 yards and two TDs.
Ohio State accumulated 603 yards of total offense to 80 for the Rattlers (1-3).
Damien Fletcher completed 10-of-16 passes for 30 yards for Florida A&M, which picked up two first downs in the game compared to 34 for the Buckeyes.