The quarterbacks played on alternating series and each performed well as the Wildcats (2-0) opened the season with a second straight win.
Siemian completed 17-of-21 passes for 270 yards with three scores. Colter (13-of-16, 110 yards) passed for one score and ran for another, finishing with 101 rushing yards on nine carries.
Tony Jones made nine catches for 185 yards and a touchdown in the victory.
The Orange (0-2) were victimized by four interceptions coughed up by Drew Allen, who passed for 280 yards and a touchdown on 27-of-41 efficiency.