Murray was complemented by Todd Gurley, who racked up 132 yards on 30 carries and two TDs -- one rushing and one receiving -- as the Bulldogs (1-1, 1-0 SEC) rebounded from a non-conference loss to Clemson last week.
Justin Wesley-Scott made three grabs for 116 yards with a score as Georgia rolled for 536 total yards against South Carolina's vaunted defense.
The Gamecocks (1-1, 0-1) could manage just six second-half points as Connor Shaw was limited to 228 yards on 16-of-25 efficiency with a pair of touchdown passes to Nick Jones.
Mike Davis ran for 149 yards and a TD on 16 attempts for South Carolina.
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