Hundley amassed 274 aerial yards with a 22-of-33 passing efficiency and added 61 yards on the ground for the Bruins, who fell to Stanford in last year's Pac-12 title game.
UCLA (1-0) broke the game open with 41 points in the second half.
Cody Fajardo paced the Wolf Pack (0-1) with 106 rushing yards and two scores.
He also completed 19-of-32 passes for 164 yards as Nevada went down in the debut of new head Coach Brian Polian.
Video of Victoria’s Secret models trying to 'twerk' hits Instagram
Wisconsin business offering 'therapeutic cuddling' forced to close