Knight completed 11-of-28 passes for 86 yards with an interception and also ran the ball 13 times for 103 yards for the Sooners (1-0), who yielded just 166 total yards on defense.
Damien Williams picked up 66 rushing yards on 16 carries and Brennan Clay ran for 43 yards with a score for Oklahoma.
Jalen Saunders led the Sooners' receiving corps with two TD grabs.
The Warhawks (0-1) were paced by senior quarterback Kolton Browning, who connected on 20-of-39 passes for 128 yards with an interception.
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