Trey Watts racked up 149 rushing yards on 25 carries and Cody Green threw for 93 yards while also scoring on the ground for the Golden Hurricane (11-3), which tied the school mark for most wins in a single season.
Thomas Roberson led Tulsa's receiving corps with two catches for 35 yards.
The Cyclones (6-7) got a 14-of-28, 170-yard combined passing performance from signal-callers S.B. Richardson and Steele Jantz in their fourth loss over five contests to end the season.
Ernst Brun compiled 102 receiving yards with a score on four receptions for Iowa State.
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