Blankenship had a scoring run of 2 yards in the second quarter and added 2- and 1-yard rushes for scores in the third period. His fourth touchdown -- another 2-yard run -- gave the Bobcats (9-4) a 45-14 lead 8 seconds into the final period.
Ohio quarterback Tyler Tettleton had first-quarter scoring passes of 3 yards to Donte Foster and 68 yards to Chase Cochran for an early Bobcat lead.
Tettleton completed 13-of-21 passes for 332 yards. Blankenship rushed 19 times for 99 yards. Neither played much in the fourth quarter.
Louisiana-Monroe (8-5), playing in its first bowl game, pulled within 14-7 with a 14-yard pass from Kolton Browning to Tavarese Maye, but the first three Blankenship touchdowns and a 38-yard Matt Weller field goal pushed Ohio's lead to 38-7.
Browning had a 1-yard touchdown pass to Kevin Steed for the Warhawks' other touchdown.
The full name of the game is the AdvoCare 100 Independence Bowl.