Wilder finished with 69 rushing yards on 10 carries. Devonta Freeman added 59 yards and a score on 13 tries for the Seminoles (11-2), who claimed a berth in the Orange Bowl with their 13th ACC crown.
E.J. Manuel (16-of-21 for 134 yards) tossed an interception in the fourth quarter and Georgia State moved the ball to near midfield in a final push.
But Florida State defensive back Karlos Williams picked off Yellow Jackets quarterback Tevin Washington to secure the victory.
Washington was held to 76 passing yards on 4-of-14 efficiency and ran for a score for Georgia Tech (6-7), which was appearing in the conference title match due to the NCAA suspension of Miami-Florida.