Golson's favorite targets were T.J. Jones and Tyler Eifert, who combined for 182 yards on 12 catches with a pair of touchdowns.
Cierre Wood racked up 150 rushing yards with a score on 11 carries for the Fighting Irish (11-0), who wrapped up a perfect 6-0 home schedule.
Notre Dame will conclude its regular season next week with a road game against Southern California.
Tanner Price picked up 153 aerial yards on 22-of-33 efficiency for Wake Forest (5-6), which was outgained 584-209.
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