Backup quarterback Jacoby Brissett -- who got the start as Jeff Driskel recovers from an ankle injury -- went 14-of-22 through the air for 154 yards and Florida (10-1, 7-1 SEC) recorded its third straight triumph.
The Gators will seek to improve their shot for an at-large BCS bowl bid in next week's season finale against No. 6 Florida State.
The Gamecocks (6-5, 5-3 Ohio Valley Conference) were paced by Marques Ivory, who tossed for 169 yards with an interception on 14-of-25 passing efficiency.
Rosie O'Donnell unveils nearly 50-pound weight loss
Iranian woman stops the execution of son's killer