Boyd completed 18-of-27 passes.
Andre Ellington and Roderick McDowell combined for 95 yards and score on the ground for the Tigers (9-1, 6-1 ACC).
Backup Clemson quarterback Cole Stoudt also tossed for score on 5-of-8 passing efficiency and DeAndre Hopkins contributed four grabs for 59 yards with a touchdown.
The Terrapins (4-6, 2-4) lost despite 102 rushing yards on 15 carries from Brandon Ross.
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