Edwards finished with 105 yards on 16 carries for the Cardinals (7-3, 4-2 MAC), who snapped Toledo's eight-game winning streak.
Keith Wenning hurled a trio of TD passes, completing 29-of-42 passes for 281 yards with three interceptions, and Ball State's defense stopped a last-chance Toledo drive to seal the win.
The Rockets (8-2, 5-1) fell despite 200 yards on 34 carries from David Fluellen, but he also lost a key fumble.
Video of Victoria’s Secret models trying to 'twerk' hits Instagram
Britney Spears debuts 'Perfume' video