Manziel ran in two scores for the Aggies (7-2, 4-2 SEC), who churned out 693 yards of total offense and led 24-0 at halftime.
The Aggies won for the seventh time in eight games while Mississippi State (7-2, 3-2) lost its second in a row after going 7-0 to start the season.
Ryan Swope caught nine passes for 121 yards for Texas A&M. Ben Malena ran for 112 yards and a touchdown.
Manziel led the Aggies to scores on their first three possessions. The Aggies picked up 36 first downs in the game to 15 for the Bulldogs.
Swim Week Miami Beach 2014 [PHOTOS]