Jared Barnett tossed a trio of scoring strikes en route to 183 yards for the Cyclones (4-1, 1-1 Big 12).
The Horned Frogs (4-1, 1-1) dropped their first game as a member of the Big 12. They were without junior starting quarterback Casey Pachall, who was suspended for at least one game following a Thursday drunken driving arrest.
Redshirt freshman Trevone Boykin stepped in and went 23-of-40 passing for 270 yards and a touchdown, but he also was picked off three times.
Celebrity Families of 2014 [PHOTOS]