The freshman signal-caller, who won the starting quarterback job over sophomore Bryan Bennett, amassed 216 yards while pacing Oregon to a 50-3 second-quarter lead.
Bennett then took over, hurling a TD toss of his own en route to 107 yards with an interception.
De'Anthony Thomas made a pair of scoring grabs for the Ducks (1-0).
Arkansas State (0-1) was led by quarterback Ryan Aplin, who struck for 305 yards and three touchdowns. He was intercepted once.
Exploding whale video goes viral on Internet
Texas principal bans speaking Spanish, stirs controversy