Hubert finished with 152 yards on 12 carries, while Daniel Sams and Braden Wilson added second-half scores as the Wildcats (1-0) pulled away for a season-opening triumph.
Collin Klein produced 169 yards and two touchdowns on 19-of-28 passing while adding 59 rushing yards for Kansas State.
Missouri State (0-1) was led by Ashton Glaser, who made his starting debut behind center and completed 22-of-44 passes for 249 yards and one interception.
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