Gurley scored twice on the ground while quarterback Aaron Murray went 15-of-26 through the air for 258 yards and three TDs for the Bulldogs (1-0).
Rantavious Wooten and Michael Bennett each caught a TD pass and Tavarres King amassed 117 yards with a score on six receptions for Georgia.
The Bulls (0-1) got a 14-of-24 passing performance from Alex Zordich. The Buffalo signal-caller tossed for 148 yards and a touchdown.
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