Hopkins amassed 119 receiving yards while filling in for the suspended Sammy Watkins, who missed the first of two games due a drug-related arrest.
Andre Ellington rushed for 231 yards, while Tajh Boyd racked up 208 aerial yards and 58 more on the ground for Clemson (1-0).
Auburn (0-1) got an 11-of-27 passing performance from Kiehl Frazier, who was making his first start for the Tigers in a game played at the Georgia Dome in Atlanta.
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