McGloin took over full-time signal-calling duties from Rob Bolden and responded by completing 17-of-26 pass attempts for 192 yards while tailback Silas Redd amassed 164 yards and a touchdown on 18 carries for Penn State (7-1, 4-0 Big Ten).
Paterno tied Eddie Robinson for the most wins as a head coach in Division 1 football history with his 408th victory.
Quarterback Dan Persa led Northwestern (2-5, 0-4), going 26-of-34 through the air for 294 yards and a TD before leaving in the fourth quarter with an injury.
Kain Colter racked up 112 all-purpose yards and Jeremy Every grabbed six passes for 109 yards in the Wildcats' loss.
Attkisson leaves CBS News, reportedly over network's 'liberal bias'
Duggar sisters unveil Christian dating rules in new book