McGloin took over full-time signal-calling duties from Rob Bolden and responded by completing 17-of-26 pass attempts for 192 yards while tailback Silas Redd amassed 164 yards and a touchdown on 18 carries for Penn State (7-1, 4-0 Big Ten).
Paterno tied Eddie Robinson for the most wins as a head coach in Division 1 football history with his 408th victory.
Quarterback Dan Persa led Northwestern (2-5, 0-4), going 26-of-34 through the air for 294 yards and a TD before leaving in the fourth quarter with an injury.
Kain Colter racked up 112 all-purpose yards and Jeremy Every grabbed six passes for 109 yards in the Wildcats' loss.
Celebrity Families of 2014 [PHOTOS]