Jerry Jones came off the bench to pour in 19 points for the Dukes (12-15, 4-10 A-10).
Ovie Soko chipped in 12.
The Billikens (25-3, 12-1) lost for the first time since Dec. 1 despite 18 points from Mike McCall Jr.
Leading scorer Dwayne Evans was held to 10 points and grabbed 12 rebounds.
Celebrity Breakups and divorces of 2014 [PHOTOS]