Perrantes went 5-of-5 overall from field and Malcolm Brodgon also netted 15 points for the Cavaliers (24-5, 15-1), who moved 1/2-game ahead in front of Syracuse in the conference standings.
Virginia will host the fourth-ranked Orange in a much-anticipated ACC showdown Saturday.
Erik Swoope netted 13 points for the Hurricanes (14-14, 5-10), who shot just 26.1 percent from the floor.
Rion Brown added 12.
Celebrity Families of 2014 [PHOTOS]