DeAndre Kane had 17 points and 11 rebounds as the Cyclones (22-5, 10-5 Big 12) reeled off a fourth straight win.
Dustin Hogue added 15 points and nine rebounds.
Naz Long also tallied 15 points for Iowa State.
The Mountaineers (15-13, 7-8) were led by Juwan Staten with 19 points.
Eron Harris added 15 and Remi Dibo totaled 14 for WVU.
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