Markus Kennedy provided 13 points with seven rebounds as the Mustangs (22-6, 11-4 AAC) bested the Huskies for a second time this season.
SMU notched a fourth win in five contests against ranked teams this season and snapped Connecticut's four-game winning streak.
Ryan Boatright and Shabazz Napier each put in 15 points for UConn (21-6, 9-5), combining to go just 8-of-28 from the field.
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