Hilliard fired in four 3-pointers and Ryan Arcidiacono added 12 points as the Wildcats (24-3, 12-2 Big East) racked up an eighth victory in nine games.
JayVaughn Pinkston dominated the boards with 11 rebounds.
The Red Storm (18-10, 8-7) had their six-game winning streak snapped despite 15 points from D'Angelo Harrison.
JaKarr Sampson supplied a double-double of 12 with 10 rebounds.
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