Jackson also hauled down six rebounds as the Tigers (20-6, 9-4 ACC) bounced back from an overtime loss to Connecticut Saturday.
Shaq Goodwin and Austin Nichols supplied 10 points each.
The Scarlet Knights (10-17, 4-10) were paced by Kadeem Jack with 22 points and 10 rebounds.
Myles Mack totaled 10 points, six assists and five rebounds.
Celebrity Breakups and divorces of 2014 [PHOTOS]