McDermott heated up in the second half, when he netted 17 of his total, and Wragge fired in six 3-pointers as the Big East-leading Bluejays (22-4, 12-2 Big East) notched a third straight win.
McDermott's trey late in the second half ignited a 15-3 run that put the game away for Creighton.
The Golden Eagles (15-11, 7-6) were paced by Todd Mayo with 13 points.
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