Justin Jackson helped out with 10 points, seven rebounds and four blocked shots for the Bearcats (24-3, 13-1 AAC), who won a second straight.
Cincinnati reeled off a 15-0 run the first half and led 40-18 at the break.
The Knights (10-14, 2-11) were paced by Isaiah Sykes with 13 points and 10 rebounds.
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