Andrew Wiggins contributed 17 points and Wayne Selden added 15 for the Jayhawks (19-6, 10-2 Big 12), who connected on 61.5 percent of their shots from the field in the rout.
They cruised despite the absence of freshman center Joel Embiid, who missed the game with a knee sprain and a sore back.
Kyan Anderson scored 25 points for the winless Horned Frogs (9-15, 0-13), who dropped a 13th straight.
Amric Fields added 12 points.
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