Prather scored 24 points and Wilbekin sank 11-of-12 free throws en route to 23 points as the Gators (23-2, 12-0 SEC) improved to 12-0 in conference play for the first time in program history.
Patric Young chipped in 10 points.
James Young and Andrew Harrison each put in 20 points for the Wildcats (19-6, 9-3), who fell for the first time in five games.
Julius Randle provided 13 points and 13 rebounds.
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