Harrell also blocked four shots as the Cardinals (20-4, 9-2 AAC) led wire-to-wire in a contest that was originally slated for Thursday but delayed a day due to a snowstorm in Philadelphia.
Russ Smith contributed 15 points and Wayne Blackshear added 13 off the bench.
Luke Hancock helped out with 11 points as Louisville posted a third straight win.
The Owls (6-17, 1-10) were paced by Will Cummings with 16 points.
Anthony Lee provided 14.