Julius Randle registered a double-double of 12 points and 11 rebounds as the Wildcats (19-5, 9-2 SEC) emerged with the win despite shooting just 30.9 percent from the field.
Aaron Harrison netted 10 points for Kentucky.
The Tigers (11-11, 3-8) remained in search of their first win over Kentucky since Jan. 11, 2000.
Chris Denson posted a game-high 26 points for Auburn.
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