Juwan Staten provided 19 points, nine assists and seven rebounds for the Mountaineers (15-10, 7-5 Big 12), who shot 53.8 percent from the field and made a case for an NCAA Tournament berth with the one-sided win.
Terry Henderson and Eron Harris each scored 16 points for WVU.
The Cyclones (18-5, 6-5) fell as leading scorer Melvin Ejim was limited to six points on 1-of-9 shooting with 12 rebounds.
Georges Niang provided 17 points and Dustin Hogue added 15 with 10 rebounds.
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