Selden connected on 5-of-7 shots from the field and Joel Embiid contributed 11 points, 12 rebounds and three blocks for Kansas (18-5, 9-1 Big 12).
Tarik Black chipped in 11 points as the Jayhawks notched an 111th straight home win against unranked opponents.
The Mountaineers (14-10, 6-5) got 22 points from Juwan Staten and 17 from Eron Harris.
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