Ejim's point total was the most-ever for a Cyclone player in a conference game, beating the old mark of 47 set by Barry Stevens in 1985.
He also dominated the boards with 18 rebounds as Iowa State (18-4, 6-4 Big 12) cruised to an easy victory.
Georges Niang provided 11 points, six rebounds and six assists.
The Horned Frogs (9-13, 0-10) were led by Kyan Anderson with 27 points.
Karviar Shepherd added 11 points and eight rebounds.
Ray Liotta sues skin care company over use of likeness
Aaron Carter is still in love with Hilary Duff