Wilbekin went 5-for-7 from the field, Casey Prather scored 15 points and Michael Frazier added 14 for Florida, (21-2, 10-0 SEC).
Trevor Young led Alabama (9-14, 3-7) with 25 points and four steals. The Crimson Tide lost its fourth consecutive game.
Alabama slowed Florida down with a solid zone defense in much of the first half and went into halftime tied 36-36. The Gators, however, outscored the Tide 42-33 the rest of the way.