Daniel Echefu had a double-double of 10 points and 10 rebounds as the Wildcats (21-2, 9-1 Big East) reeled off a fifth straight win.
The Pirates (13-10, 4-6) were paced by Sterling Gibbs with 16 points.
Eugene Teague helped out 10 and six rebounds.
Interpol investigating stolen passports on missing flight
Dennis Rodman pledges to end trips to North Korea