Parker also had eight rebounds in the Duke (18-5, 7-3 ACC) victory, who rebounded from an overtime loss to Syracuse on Saturday.
Devin Thomas scored 14 points for Wake Forest (14-9, 4-6) in their third consecutive loss. Arnaud-William Adala Moto chalked up a double-double of 10 points and 10 rebounds.
Duke led 46-33 at halftime and shot a sharp 50.9 percent from the field, including 12-of-26 from 3-point range.
Celebrity Families of 2014 [PHOTOS]