Cooney finished 11-of-15 from the field and 9-of-12 from long range for the Orange (22-0, 9-0 ACC), who held off the Fighting Irish down the stretch to remain unbeaten and extend the best start in school history.
Notre Dame whittled a 13-point halftime deficit down to three in the closing minutes, but Cooney answered with six points during an 8-1 run to put the contest away.
The Irish (12-11, 3-7) were led by Garrick Sherman with 16 points.
Steve Vasturia added 13.
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