Smith sank 9-of-14 from the field as the Cardinals (18-4, 7-2 AAC) bounced back from a 69-66 home loss to Cincinnati Thursday.
Luke Hancock (16 points), Montrezl Harrell (14) and Wayne Blackshear (10) also reached double figures for Louisville, which jumped off to a 12-1 advantage and never trailed.
The Golden Knights (9-10, 1-7) were led by Tristan Spurlock with 20 points.
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