Jordan Woodard added 18 points as the Sooners (17-4, 6-2 Big 12) corralled a fourth straight win.
Tyler Neal sank 5-of-6 shots from the field to finish with 15 points.
The Cowboys (16-4, 4-3) dropped a second in three games despite 22 points from Marcus Smart.
Phil Forte netted 20, including six 3-pointers.
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