Will Artino came off the bench to pop in 14 points as the Bluejays (17-3, 7-1 Big East) recorded a 12th win in 13 games.
Ethan Wragge put in 12 points, Devin Brooks added 11 and Jahenns Manigat provided 10 for Creighton.
Markel Starks led the Hoyas (11-8, 3-5) with 21 points.
D'Vauntes Smith-Rivera chipped in 18 as Georgetown dropped a fourth straight.
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