Cincinnati held only a three-point lead at the break, but dominated the second period thanks to 19 points from Kilpatrick and 12 from Justin Jackson.
The Bearcats advanced to 18-2 for the season and are 7-0 in the American Athletic Conference. They have a one-game lead over Louisville and will meet the Cardinals next Thursday.
Central Florida (9-8, 1-5 AAC) was paced by 12 points from Calvin Newell.
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