Lamar Patterson came up with 13 points and six assists for the Panthers (17-2, 5-1 ACC), who were coming off a disappointing 59-54 loss to No. 2 Syracuse Saturday.
Josh Newkirk came off the bench to pop in 10 points.
Leading scorer K.J. McDaniels was held to 11 points for the Tigers (13-5, 4-2), who connected on just 16-of-50 shots from the field.