Wragge tied Kyle Korver's 2003 school record for most 3-pointers in a game for the Bluejays (16-3, 6-1 Big East), who broke a Big East record with 21 makes from beyond the arc overall.
Doug McDermott added five treys to finish with 23 points as Creighton logged just its third-ever victory over a Top 5 opponent.
Jahennis Manigat had four triples on his way to 19 points and Austin Chatman distributed 10 assists.
The Wildcats (16-2, 5-1) were led by James Bell with 19 points.
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